Research

What is Noni? Why Tahiti? Elements of Noni Science Meets Tradition Tahitian Noni® Products

CLINICAL STUDIES-ANTIOXIDANTS

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Related Literature:

Wang, M.Y., C. SU, "Cancer Preventive Effect of Morinda citrifolia (Noni)." Annals New York Academy of Sciences. 2. Su, Bao-Ning, Alison d. Pawlus, Hyun-Ah Jung, William J. Keller, Jerry L. McLaughlin, A. Douglas Kinghorn. "Chemical Constituents of the Fruits of Morinda citrifolia (Noni) and Their Antioxidant Activity." J. Nat. Prod., 68, 592-595 (2005). 3. Kamiya, Kohei, Toyei Tanaka, Hanani Endang, Mansur Umar, Toshiko Satake. "Chemical Constituents of Morinda citrifolia Fruits Inhibit Copper-Induced Low-Density Lipoprotein Oxidation." Journal of Agricultural and Food Chemistry, 2004. 4. Poster Abstracts. Subsection: Wang, M.Y., S. Su, A.D. Nowicki, J.Jensen, and G. Anderson. "Morinda citrifolia and Cancer Prevention." Available online at http://www.jca.gr.jp/pdf/aj7ps_a.pdf (p. A23). 5. Wang, M. Y., A. Cheerva, C. Su, J. Jensen, D. Nowicki, G. Anderson, S. Jensen, J. W. Fritz. "Protective Effects of Morinda citrifolia (Noni) on Plasma SAR and LPO in Current Smokers." XI Biennial Meeting of the Society for Free Radical Research International, 2002. A summary of this study is available online at http://www.chinaphar.com/1671-4083/23/1127.pdf (p. 1136). 6. Zin, Z. Mohd, A. Abdul Hamid, A. Osman, N. Saari, "Antioxidative activities of chromatographic fractions obtained from root, fruit, and leaf of Mengkudu (Morinda citrafolia L.)." Food Chemistry 94, 169-178 (2006). 7. Ying-Mian, Wang, Brett J. West, C. Jarakae Jensen, Diane Nowicki, Su Chen, Afa K. Palu, Gary Anderson, "Morinda citrifolia (Noni): A literature review and recent advances in Noni research." Acta Pharmacologica Sinica, 1135-1136 (2002). 8. Wang, Mian-Ying, Eric Henley, Lin Peng, Vicki Weidenbacher-Hoper, Joella Warner, Nawal Lutfiyya, Gary Anderson. "Morinda citrifolia Reduces Cancer Risk in Current Smokers." AACR-JCA Joint International Conference (January 21-25, 2007). Available online here. 9. Zin, Z. Mohd. "Isolation and Identification of Antioxidative Compound from Fruit of Mengkudu (Morinda citrifolia)." International Journal of Food Properties, Vol. 10, 363-373 (2007). 10. S. Vimala & Mohd. Illham Adenan. "Malaysian Tropical Forest Medicinal Plants: A Source of Natural Antioxidants." Journal of Tropical Forest Products 5(1): 32-38 (1999). 11. Park, YK, E. Park, Kim JS, Kang MH. "Daily grape juice consumption reduces oxidative DNA damage and plasma free radical levels in healthy Koreans." Mutat. Res. 529 (1-2): 103 (Feb 2004). 12. O’Byrne, Dawn J., Sridevi Devaraj, Scott M. Grundy, and Ishwarlal Jialal. "Comparison of the antioxidant effects of Concord grape juice favonoids and a-tocopherol on markers of oxidative stress in healthy adults." Am. J. Clin. Nutr. 76: 1367-74 (2002). 13. Prior, R.L., Gu L., Wu X., Jacob R. A., Sotoudeh G., Kader A.A., Cook, R. A. "Plasma antioxidant capacity changes following a meal as a measure of the ability of a food to alter in vivo antioxidant status." J. Am. Coll. Nutr. 26(2): 170-81 (2007). 14. Harada, Shinichi. Wakako Harnabe, Kohei Kamiya, Toshiko Stake, Shogo Tokuyama. "The preventive effect of the juice of Morinda citrifolia against the ischemic brain injury." Journal of Pharmacological Sciences, Vol. 103, Supp. 1:228P (2007). 15. Palu, Afa Kehaati. "Tahitian Noni Juice: Its Antioxidant Capacity is Only a Part of the Repertoires of its Scientifically Proven Health Benefits." Tahitian Noni International Research Center, American Fork, Utah 2004. 16. Brett J. West, C. Jarakae Jensen. Noni juice increases athlete endurance via antioxidant mechanism. Poster # 208. Joint Northwest and Rocky Mountain Regional Meeting of the American Chemical Society. June 17, 2008. Park City, Utah, USA.

Articles related to Tahitian Noni strengthening of the IMMUNE SYSTEM

1. Hirazumi, A., E. Furusawa, S. C. Chou, Y. Hokama. "Anticancer Activity of Morinda citrifolia (Noni) on Intraperitoneally Implanted Lewis Lung Carcinoma in Syngeneic Mice." Proc. West. Pharmocol. Soc. 37: 145-146 (1994). 2. Hirazumi, Anne, Eiichi Furusawa. "An Immunomodulatory Polysaccharaide-Rich Substance from the Fruit Juice of Morinda citrifolia (Noni) with Antitumour Activity." Phytotherapy Research 13, 380-387 (1999). 3. Furusawa, Eiichi, Anne Hirazumi, Stephen Story, Jarakae Jensen. "Antitumour Potential of a Polysaccharaide-rich Substance from the Fruit Juice of Morinda citrifolia (Noni) on Sarcoma 180 Ascites Tumour in Mice." Phytother, Res. 17, 1158-1164 (2003). 4. Wong, Desmond K.W., MD. "Are Immune Responses Pivotal to Cancer Patient’s long term survival? Two Clinical Case-Study Reports on the Effects of Morinda citrifolia (Noni)." Hawaii Medical Journal, Vol. 63, (June 2004). 5. Liu, Guangming. Ann Bode, Wei-Ya Ma, Shengmin Sang, Chi-Tang Ho, Zigang Dong. "Two Novel Glycosides from the Fruits of Morinda Citrifolia (Noni) Inhibit AP-1 Transactivation and Cell Transformation in the Mouse Epidermal JB6 Cell Line." Cancer Research 61, 5749-5756 (2001). 6. Hirazumi, A. E. Furusawa, S.C. Chou, Y. Hokama. "Immunomodulation Contributes to the Anticancer Activity of Morinda citrifolia (noni) Fruit Juice." Proc. West. Pharmacol. Soc. 39: 7-9 (3996). 7. Arpornsuwan, Teerakul and Tadsanee Punjanon. "Tumor Cell-Selective Antiproliferative Effect of the Extract from Morinda citrifolia Fruits." Phytother. Res. 20:515-517 (2006). 8. Brooks, V.J. J. Xu, J. Cai, S.F. Peek, T. Schriver, R.G. Godbee, R.D Schultz, B.J. Darien. "Enhanced Mononuclear Phagocytic Activity of Gram-Negative Bacteria in Calves Fed Morinda Cintrifolia (Tahitian Noni) Puree." 9. Chjen-Cheng Chen, Dong-Bor Yeh, Shih-Ying Chen. "Study on the extracts of Morinda citrifolia protection against oxidative damage to human blood cells." Dept. of Biotechnology and Dept. of Health and Nutrition, Chia Nan University of Pharmacy and Science, Taiwan. 10. J. Xu, A.C. McSloy, B.K. Anderson, R.G. Godbee, S.F. Peek, B.J. Darien.

"Tahitian Noni Equine Essentials":

A Novel and Anti-Inflammatory and a COX-2 Inhibitor which Regulates LPS-Induced Inflammatory Mediator Expression in Equine Neonatal CARDIOVASCULAR HEALTH and Research http://www.blackwell-synergy.com/doi/full/10.1111/j.1750-3841.2006.00164.x 2. Palu, ‘AK, Santiago, RA, West, BJ, et al. The Effects of Morinda citrifolia L. Noni on High Blood Pressure: A Mechanistic Investigation and Case Study. American Chemical Society Symposia Series (In press). 3. Wang, M-Y, Nowicki, D, Anderson, G. The Heart Protection Study: Improvement of Lipoprotein Profiles in Current Smokers Receiving Morinda citrifolia (Noni) Fruit Juice. 2004. Circulation, J Am Heart Assoc, 109: 71—144 (Abs #P93). Available online at http://circ.ahajournals.org/cgi/reprint/109/7/e71. 4. West BJ, Jensen CJ, Westendorf J, and White LD. A Safety Review of Noni Fruit Juice. Journal of Food Science 2006 October; 71(8): R100-R106. Available online at http://www3.interscience.wiley.com/cgi-bin/fulltext/118601402/HTMLSTART. 5. Kamiya K, Tanaka Y, Endang H, Umar M, Satake T. Chemical constituents of Morinda citrifolia fruits inhibit copper-induced low-density lipoprotein oxidation. J Agric Food Chem. 2004 Sep 22; 52(19): 5843-8. 6. Ayanbule F, Wang MY, Peng L, Nowicki J, Anderson G, Nowicki D. Antithrombotic Effect of Morinda citrifolia (Noni) Fruit Juice on the Jugular Vein Thrombosis Induced by Ferric Chloride in Male Adult SD Rats. Arterioscler. Thromb. Vasc. Biol. 2006; 26; e104.

Improves Energy/Endurance/Physical Performance

1. Ma, De-lu, Chen X. Su, Jian-hua Gao, Tin-zhong Liu, Brett J. West. "Evaluation of the Ergogenic Potential of Noni Juice." Phytother. Res. (in press) (2007). 2. Issell, Brian F., Carolyn C. Gotay, Ian Pagano. "Quality of Life (QOL) Assessment in a Phase I Trial of Noni." Official Journal of the International Society for Quality of Life Research, Vol. 14, No. 9 (Nov. 2005). Available online at http://www.isoqol.org/2005ConfAbstracts.pdf. 3. Thaman, R.R. "Kiribati Agroforestry: Trees, People and the Atoll Environment." Atoll Research Bulletin, No. 333 (1990). 4. Zhongguo Linchuang Shiyong Tixue Zazhi. "Studies on Effects of Tahitian Noni Juice on Postponable Senility." China Journal of Clinical Practical Medicine, Vol. 2, No. 2 (Feb. 2007). 5. Letter to the Editor. "Effects of Morinda Citrifolia on Quality of Life and Auditory Function in Postmenopausal Women." The Journal of Alternative and Complementary Medicine, Vol. 10, No. 5, 737-724 (2004). . 6. Palu, ‘Afa K., Chen Su, Bin-Nan Zhou, Brett West, Shixin Deng, Jarakae Jensen. "The Inhibitory Effects of Morinda citrifolia L. noni on Phosphodiesterase Enzymes: The Possible Mechanisms for Increasing Energy and Improving Diabetic Conditions." IV International Conference on Aromatic and Medicinal Plants from French Overseas Regions. Tahiti. July 10-13, 2006. 7. Ying-Mian, Wang, Brett J West, C. Jarakae Jensen, Diane Nowicki, Su Chen, Afa K. Palu, Gary Anderson, "Morinda citrifolia (Noni): A literature review and recent advances in Noni research." Act a Pharmacologica Sinica, 1135-1136 (2002). 8. Brett J. West, C. Jarakae Jensen. Noni juice increases athlete endurance via antioxidant mechanism. Poster # 208. Joint Northwest and Rocky Mountain Regional Meeting of the American Chemical Society. June 17, 2008. Park City, Utah, USA.

ATHLETIC ENDURANCE/RECOVERY and Research

1. TNJ and Athletic Endurance This study by Tahitian Noni scientists shows people who drink TAHITIAN NONI® Juice experience a 21% increase in athletic performance, due to high antioxidant activity. Athletes who drank TAHITIAN NONI® Juice were able to run longer, faster and with more endurance.* http://www.academicjournals.org/jmpr/PDF/pdf2008/July/Palu%20et%20al.pdf

ADDITIONAL RESEARCH

1. Literature review and recent advances This is a study conducted by Tahitian Noni scientists outlining the history, research and benefits behind TAHITIAN NONI® Juice. The study includes references to Dr. Ralph Heinicke’s groundbreaking research. A great overview of everything we now know about the noni fruit. http://www.chinaphar.com/1671-4083/23/1127.pdf 2. A complete review of TAHITIAN NONI® Juice Noni has been used by Tahitians for thousands of years, but only recently has it become a popular item for mainstream consumers. This popularity has raised several questions about the noni fruit, and in this study Tahitian Noni scientists conduct several tests to verify that the noni fruit and TAHITIAN NONI Juice are, in fact, safe for consumption. http://www.blackwell-synergy.com/doi/full/10.1111/j.1750-3841.2006.00164.x 3. Maintaining joint health Researchers study the effects of TAHITIAN NONI® Juice on neck and joint pain, and find that those who combine TAHITIAN NONI® Juice with traditional therapy experience a significant decrease in pain. http://www.ajol.info/viewarticle.php?id=29710 4. Improving quality of life for postmenopausal women Tahitian Noni International scientists study the effects of TAHITIAN NONI® Juice on postmenopausal women. Researchers study the effects of the juice as it relates to bone density, circulation and other postmenopausal issues. http://www.liebertonline.com/doi/abs/10.1089%2Facm.2004.10.737 5. Improving quality of life for cancer patients Cancer patients were given freeze-dried noni in capsule form to test its effects on their quality of life. Noni has been reported to increase function, and it has even been reported to have anti-cancer activity. http://www.isoqol.org/2005ConfAbstracts.pdf 6. Reducing cancer risk in smokers Led by Dr. Mian Ying-Wang, researchers record the effects of TAHITIAN NONI® Juice on smokers who are in danger of contracting cancer. The juice’s antioxidant levels may have anti-cancer activity, according to the study, and the risk of cancer was decreased significantly among those smokers who drank 1-4 oz. of TAHITIAN NONI® Juice for one month. http://www.abstractsonline.com/viewer/viewAbstract.asp?CKey={C9ADCEF2-C9A3-4D02-922B-1982DDD964AF} &MKey={E3F4019C-0A43-4514-8F66-B86DC90CD935}&AKey={728BCE9C-121B-46B9-A8EE-DC51FDFC6C15}&SKey={2C920D5B-ABFF-48AE-87CD-2A02FF72788B}

How NONI works?

Dr. Ralph Heinicke , a noted American biochemist, had a potentially groundbreaking revelation while studying pineapple enzymes. He realized that a certain alkaloid called Xeronine may play a key role in encouraging proper cell function and growth in the human body. Xeronine is formed in the intestine, where a chemical reaction occurs between Proxeronine and Proxeronase . Dr. Heinicke realized that these two substances in the reaction exist in abundance in the Noni fruit..